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Lajwanti Rajinder Singh Bedi.pdf javapal




Category:1947 short stories Category:Partition of India in fiction Category:Urdu short stories Category:Urdu fiction Category:1947 booksSalvia divinorum (Diviner's sage) is a psychoactive herb that has been used by people of the Mazatec, Huichol, and Mataco Indian groups of Guatemala for ritual use since at least the 16th century. Salvia divinorum is currently illegal in Guatemala and was recently prohibited by the United States Drug Enforcement Administration. Legalization of salvia in the US and internationally has encouraged research into the pharmacology and pharmacokinetics of salvinorin A, the major active alkaloid of the plant. Unlike conventional opiates, salvinorin A does not bind with opioid receptors and activates G-protein-coupled receptors (GPCRs) and ion channels. In humans, salvinorin A-induced hallucinations, perceptual distortions, and increased heart rate are most consistent with the activation of 5-HT2A serotonin receptors. Although THC (the psychoactive component of cannabis) also binds to 5-HT2A receptors, there are major differences between salvinorin A and THC, especially with regard to the mechanisms by which salvinorin A produces its effects. The long-term goal of the proposed research is to understand how salvinorin A acts at 5-HT2A receptors and activate G-protein coupled receptor (GPCR) signaling pathways. The proposed research will test the hypothesis that salvinorin A and related compounds bind to 5-HT2A receptors and activate G-protein mediated signaling pathways by allosteric and/or orthosteric mechanisms. The hypotheses will be tested using patch clamp electrophysiology, binding assays, site-directed mutagenesis, and receptor heterologous expression in HEK293 cells. The specific aims of the proposed research are to: (1) determine whether salvinorin A and related compounds bind to 5-HT2A receptors allosterically; (2) determine whether salvinorin A or its analogues activate G proteins; (3) determine whether salvinorin A and its analogues activate G-protein signaling via orthosteric and/or allosteric interactions. The findings from the proposed research will advance the understanding of salvinorin A's mechanisms of action at 5-HT2A receptors, which may lead to better treatments for human disorders and behavioral conditions that can be




Lajwanti Rajinder Singh Bedi.pdf javapal

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